Now in its third edition, Principles of Pharmacology presents content in a conceptual framework that maximizes understanding and retention and minimizes rote memorization. It takes students “beyond the disease” and deep into physiologic, biochemical, and pathophysiologic systems where drugs activate or inhibit these systems by interacting with molecular and cellular targets. This unique approach ensures understanding of the mechanisms of drug actions on the body, and ultimately, in treating the human patient. Ideal for introductory pharmacology courses that emphasize critical thinking, molecular understanding, systemsbased integration, and clinical preparation, the text: features chapteropening clinical cases and questions to establish a context for the discussion and the answers that follow; presents signature drug summary tables, updated and organized by mechanism of action, with information on clinical applications, adverse effects, contraindications, and therapeutic considerations; incorporates NEW fullcolor illustrations throughout, suiting the needs of visual learners and more effectively presenting concepts covered in the narrative; integrates timely content, including recently approved drugs as well as current research on drug mechanisms of action; delivers course and review material appropriate for students through a uniquely collaborative authorship consisting of medical students, residents, and faculty.