This issue of Clinics in Geriatric Medicine, guest edited by Mary Ann Zagaria, PharmD, is devoted to Polypharmacy. Articles in this outstanding issue include: Centers for Medicare and Medicaid Services Support for Medication Therapy Management (Enhanced Medication Therapy Management): Testing Strategies for Improving Medication Use Among Beneficiaries Enrolled in Medicare Part D; The Role of Patient Preferences in Deprescribing; Polypharmacy Reduction Strategies: Tips on Incorporating American Geriatrics Society Beers and Screening Tool of Older People’s Prescriptions Criteria; Polypharmacy and Delirium in Critically Ill Older Adults: Recognition and Prevention; Geriatric Polypharmacy: Pharmacist as Key Facilitator in Assessing for Falls Risk; Medication Reconciliation in Long-Term Care and Assisted Living Facilities: Opportunity for Pharmacists to Minimize Risks Associated with Transitions of Care; Can Managed Care Manage Polypharmacy?; Medication Risk Mitigation: Coordinating and Collaborating with Health Care Systems, Universities, and Researchers to Facilitate the Design and Execution of Practice-Based Research; and Geriatric Polypharmacy: Two Physicians’ Personal Perspectives.

With the use of multiple medications in the elderly patient comes the risk of drug-related problems. This issue covers polypharmacy in the elderly patient with topics that include: The Interplay between Polypharmacy, Geriatric Conditions, and Adverse Drug Reactions, Factors Leading to Excessive Polypharmacy, Clinical Practice Guidelines for Chronic Diseases and How They Contribute to Polypharmacy, Polypharmacy in Nursing Home Residents, Psychotropic Polypharmacy, Deprescribing Trials: Methods to Reduce Polypharmacy and the Impact on Prescribing and Clinical Outcomes, Ethical Framework for Medication Discontinuation in Nursing Home Residents with Limited Life Expectancy, Pharmacokinetics in the Elderly and the Interaction with Polypharmacy, Medication Adherence to Multi-drug Regimens, Improvements in Electronic Prescribing to Reduce Inappropriate Medication Use and Polypharmacy, and Tools to Decrease Polypharmacy.