Myeloid-Derived Suppressor Cells, Volume 184 in the Methods in Cell Biology series includes comprehensive protocols to assess the role of myeloid-derived suppressor cells (MDSCs), an immature, heterogenous cell population from the myeloid lineage with a potent immunosuppressive activity in a variety of diseases. This volume includes interesting protocols that address the Detection of myeloid-derived suppressor cells by flow cytometry, Determination of murine myeloid-derived suppressor cells by flow cytometry, Isolation of Myeloid-Derived Suppressor Cells (MDSC) from Endometriotic Mice Model and their Immunomodulatory Functions, Simple protocol for measuring CD11b+ GR-1+ (Ly6C+/Ly6G+) myeloid cells from a minimum volume of mouse peripheral blood, and much more.

Additional chapters cover Assessment of myeloid-derived suppressor cell differentiation ex vivo, Single clonal tracking on biomimetic microtextured platforms for real-time guided migration analysis of myeloid-derived suppressor cell dissemination characteristics ex vivo, Isolation and immunosuppressive functions of myeloid-derived suppressor cell-derived exosomes, Characterization of lysosomal acid lipase in Ly6G+ and CD11c+ myeloid-derived suppressor cells, In Vitro Osteoclastogenesis Assessment using Murine Myeloid-derived Suppressor Cells, Estimating Nitric Oxide (NO) from MDSCs by Griess Method, and In vitro generation of myeloid-derived suppressor cells (MDSCs) from hematopoietic progenitor cells (HPCs).

• Provides the authority and expertise of leading researchers in myeloid-derived suppressor cells
• Includes comprehensive and detailed protocols to assess the detrimental role of myeloid-derived suppressor cells
• Presents the latest release in the Methods in Cell Biology series

Myeloid-Derived Suppressor Cells; Volume 375 includes comprehensive and detailed reviews on the current advances in myeloid derived suppressor cells; an immature; heterogenous cell population from the myeloid lineage that has been extensively described in the last decades due to its potent immunosuppressive activity in a variety of pathologies. Chapters in this new release include Cancer-cell-intrinsic mechanisms regulate myeloid-derived suppressor cells through cytokine networks; Role of myeloid-derived suppressor cells in head and neck cancer; Role of myeloid-derived suppressor cells in breast cancer; Role of myeloid-derived suppressor cells in endometriosis; Role of myeloid-derived suppressor cells in ovarian cancer; Role of myeloid-derived suppressor cells in sarcoma; and more.

• Contains chapters led by selected experts on the topic of myeloid-derived suppressor cells
• Includes comprehensive and detailed knowledge on myeloid-derived suppressor cells in different diseases
• Offers a wide range of perspectives on specific diseases